ANTXR1 Polyclonal Antibody for Human(Homo sapiens) | EIAab.comANTXR1 Polyclonal Antibody for Human(Homo sapiens)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > ANTXR1(Gene name) > Human

ANTXR1 (Gene name),

Anthrax toxin receptor 1 (Protein name ), ANTR1_HUMAN from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

ANTXR1(ATR;TEM8);

Protein name:

Anthrax toxin receptor 1;

Alternative:

Tumor endothelial marker 8;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with gelatin and type 1 collagen. Interacts with the actin cytoskeleton. Binds to the protective antigen (PA) of Bacillus anthracis. Binding does not occur in the presence of calcium.

Function:

Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.

Subcellular Location:

Cell membrane Single-pass type I membrane protein Cell projection lamellipodium membrane Single-pass type I membrane protein Cell projection filopodium membrane Single-pass type I membrane protein At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia.

Protein Attributes:

Sequence length:

564

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

564:

RAPPPSRPPP | RPSV

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

String:

Q9H6X2

Pfam:

PF05586

UniGene:

Hs.165859

MIM:

230740

SMR:

Q9H6X2

KEGG:

hsa:84168

MIM:

602089

STRING:

9606.ENSP00000301945

Uniprot:

Q9H6X2

FOR

ELISA Kit for Human Anthrax toxin receptor 1

Cat.:

E9613h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Human Anthrax toxin receptor 1

Cat.:

E9613m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

ELISA Kit for Human Anthrax toxin receptor 1

Cat.:

E9613r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Anthrax toxin receptor 1

Cat.:

U9613h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Human Anthrax toxin receptor 1

Cat.:

U9613r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Anthrax toxin receptor 1

Cat.:

U9613m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Human Anthrax toxin receptor 1

Cat.:

P9613Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Anthrax toxin receptor 1

Cat.:

P9613Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Human Anthrax toxin receptor 1

Cat.:

P9613Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Anthrax toxin receptor 1

Protein for Human Anthrax toxin receptor 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Genes expressed in human tumor endothelium."
St Croix B. , Rago C. , Velculescu V.E. , Traverso G. , Romans K.E. , Montgomery E. , Lal A. , Riggins G.J. , Lengauer C. , Vogelstein B. , Kinzler K.W.
Science289:1197-1202(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Identification of the cellular receptor for anthrax toxin."
Bradley K.A. , Mogridge J. , Mourez M. , Collier R.J. , Young J.A.T.
Nature414:225-229(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);INTERACTION WITH ANTHRAX TOXIN
3.

"Broad expression analysis of human ANTXR1/TEM8 transcripts reveals differential expression and novel splizce variants."
Vargas M. , Karamsetty R. , Leppla S.H. , Chaudry G.J.
PLoS ONE7:E43174-E43174(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6);ALTERNATIVE SPLICING
tissue: Brain.
tissue: Prostate.
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 184-564 (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4);VARIANT LYS-7
5.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
tissue: Kidney.
7.

"Human capillary morphogenesis protein 2 functions as an anthrax toxin receptor."
Scobie H.M. , Rainey G.J.A. , Bradley K.A. , Young J.A.T.
Proc. Natl. Acad. Sci. U.S.A.100:5170-5174(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ANTHRAX TOXIN
tissue: Placenta.
8.

"An unappreciated role for RNA surveillance."
Hillman R.T. , Green R.E. , Brenner S.E.
Genome Biol.5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S)
9.

"TEM8 expression stimulates endothelial cell adhesion and migration by regulating cell-matrix interactions on collagen."
Hotchkiss K.A. , Basile C.M. , Spring S.C. , Bonuccelli G. , Lisanti M.P. , Terman B.I.
Exp. Cell Res.305:133-144(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION;INTERACTION WITH TYPE 1 COLLAGEN AND GELATIN;TISSUE SPECIFICITY
10.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-362;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
11.

"Anthrax toxin receptor 1/tumor endothelium marker 8 mediates cell spreading by coupling extracellular ligands to the actin cytoskeleton."
Werner E. , Kowalczyk A.P. , Faundez V.
J. Biol. Chem.281:23227-23236(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH TYPE 1 COLLAGEN; THE ACTIN CYTOSKELETON AND BACILLUS ANTHRACIS PROTECTIVE ANTIGEN
12.

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-184
tissue: Leukemic T-cell.
13.

"Mutations in ANTXR1 cause GAPO syndrome."
Stranecky V. , Hoischen A. , Hartmannova H. , Zaki M.S. , Chaudhary A. , Zudaire E. , Noskova L. , Baresova V. , Pristoupilova A. , Hodanova K. , Sovova J. , Hulkova H. , Piherova L. , Hehir-Kwa J.Y. , de Silva D. , Senanayake M.P. , Farrag S. , Zeman J. , more...
Am. J. Hum. Genet.92:792-799(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN GAPO
14.

"The structure of tumor endothelial marker 8 (TEM8) extracellular domain and implications for its receptor function for recognizing anthrax toxin."
Fu S. , Tong X. , Cai C. , Zhao Y. , Wu Y. , Li Y. , Xu J. , Zhang X.C. , Xu L. , Chen W. , Rao Z.
PLoS ONE5:E11203-E11203(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 38-220;SUBUNIT;INTERACTION WITH ANTHRAX TOXIN;DISULFIDE BOND
15.

"Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma."
Jinnin M. , Medici D. , Park L. , Limaye N. , Liu Y. , Boscolo E. , Bischoff J. , Vikkula M. , Boye E. , Olsen B.R.
Nat. Med.14:1236-1246(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HCI SUSCEPTIBILITY THR-326

Product Feedback Wall

* Email:
*Comments: